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Further information about databases considered for inclusion is contained in Appendix 1ĬOVID-19 cohorts: Two non-mutually exclusive cohorts were defined (Appendix 2)ĭiagnosed cohort were defined as patients having a clinical diagnosis and/or positive test for SARS-CoV-2 from outpatient or inpatient records. Data from Europe included the Spanish Information System for Research in Primary Care (SIDIAP) database the Dutch Integrated Primary Care Information (IPCI) database, LPD (Longitudinal Patients Database) France, LPD Italy and the UK Clinical Practice Research Datalink (CPRD).

Data from South Korea included the Health Insurance Review & Assessment Service (HIRA) database. Supplementary Figure S1 presents the database selection process for this studyĭata from the United States included: the University of Colorado Anschuz Medical Campus Health Data Compass (CU-AMC HDC), the Columbia University Irving Medical Center data warehouse (CUIMC), HealthVerity, Stanford Medicine Research Data Repository (STARR-OMOP), IQVIA Open Claims, Optum de-identified Electronic Health Record Dataset and the United States Department of Veterans Affairs (VA-OMOP). This minimum threshold was considered appropriate to estimate the prevalence of a previous condition or 30-day risk of an outcome affecting 10% of the study population. Th November 2020, 13 that had a minimum sample size of 140 COVID-19 patients with COPD were included. Of the nineteen databases available on 28

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The Charybdis protocol and source code is available via open access ( All data for were standardized to the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM)ĩ. The Characterizing Health Associated Risks and Your Baseline Disease In SARS-COV-2 (CHARYBDIS) study is a multinational cohort study using retrospective electronic health records and claims data on COVID-19 patients from three continents, the North America (US), Europe, and Asiaħ. The use of IQVIA OpenClaims and IPCI was exempted from IRB approval for COVID-19 research. The use of CPRD was approved by the Independent Scientific Advisory Committee (ISAC) (protocol number 20_059RA2). The use of SIDIAP was approved by the Clinical Research Ethics Committee of the IDIAPJGol (project code: 20/070-PCV).

The research was approved by the Columbia University Institutional Review Board as an OHDSI network study.

The use of VA data was reviewed by the Department of Veterans Affairs Central Institutional Review Board (IRB), was determined to meet the criteria for exemption under Exemption Category 4(3), and approved for Waiver of HIPAA Authorization. STARR-OMOP had approval from IRB Panel #8 (RB-53248) registered to Leland Stanford Junior University under the Stanford Human Research Protection Program (HRPP). Methods Ethical approvalĪll the data partners received Institutional Review Board (IRB) approval or exemption. The aim of this study was to perform a large-scale, federated network, descriptive characterization study reporting the demographics, comorbidities, and outcomes of COPD patients with COVID-19 at the point of diagnosis and hospitalisation. Viral respiratory tract infections are common triggers for exacerbations resulting in increased morbidity and mortality yet it is uncertain how often people with COPD with COVID-19 present with exacerbations Larger comparisons from geographically diverse cohorts that also include patients with milder COVID-19 illness provide a more compelling picture and improve generalisability. Whilst some studies suggest that the prevalence of COPD among COVID-19 patients may be lower than the prevalence of COPD in the general population COPD is still considered a risk factor for severe COVID-19 diseaseĮstimates for the prevalence of COPD among COVID-19 patients typically come from small, single-centre hospitalised cohorts and examine a limited range of patient characteristics and outcomesģ. The prevalence of identified COPD among COVID-19 patients has ranged from 0.8% to 38% in the literature depending upon the cohort studiedģ. The symptoms and complications of COVID-19 have been compared to seasonal influenza resulting in national policy measures classifying chronic obstructive pulmonary disease (COPD) patients as high risk and advising them to take additional protective measuresĢ. Coronavirus disease 2019 (COVID-19) can lead to severe lung injury and pneumonia, acute kidney injury, cardiovascular complications, and death. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over 200 million patients and resulted in more than 4.2 million deaths worldwide as of April 2021ġ.